Stage 1: This occurs within 30 minutes to 12 hours and looks similar to alcohol poisoning. (, If exposed to the eyes and facial area, propylene glycol can also be an irritant and cause mild, Propylene glycol is used in many IV medications, including, , an anxiety-reducing and seizure treatment medication. (1) Another name for it is “propane-1,2-diol,” which is sometimes used when listing it as a compound on ingredient labels. to ensure their children’s health. Inside the glycol (another term for a diol), the molecule contains two groups of hydroxyl that are attached to different carbon atoms. ), The first three of these points seem to be encouraging. Propylene glycol increases your skin’s propensity to absorb whatever it comes into contact with. One such patient was an 8-month-old who suffered a heart attack after four doses of topical medication to treat a burn. "Propylene glycol functions as a humectant food additive and preservative. Make use of it! So, although propylene glycol may not be as terrifying as some people claim, it does have enough red flags to cause me to recommend avoiding it. I did mention earlier that propylene glycol is not considered bioaccumulative (builds up over time in the bloodstream). The research surrounding this substance is limited in regard to many types of cases, while it’s still a legal ingredient in many foods, including flavored iced coffees, and other products. The Food and Drug Administration (FDA) has classified propylene glycol as an additive that is “generally recognized as safe” for use in food. You can also use raw butter instead of margarine for an immediate health booster to your cooking. EYEWASH STATION ADDITIVE CONCENTRATE- chlorhexidine gluconate and propylene glycol liquid Out of scope - Out of scope for RxNorm and will not receive RxNorm normal forms. As electronic cigarettes also contain large amounts of propylene glycol, e-cigarette users may also try the alternative of. Consumers were amazed and frustrated to hear that their favorite foods and drinks might contain the chemical, exacerbated by its presence in so many other daily products. > The Association of American Feed Control Officials (AAFCO) has no limit to the amount of propylene glycol in dog food, Vlieks says. Our team includes licensed nutritionists and dietitians, certified health education specialists, as well as certified strength and conditioning specialists, personal trainers and corrective exercise specialists. The raw materials in latex paint contain many emissions. Dr. Josh Axe is on a mission to provide you and your family with the highest quality nutrition tips and healthy recipes in the world...Sign up to get VIP access to his eBooks and valuable weekly health tips for FREE! When administered large doses of Lorazepam, adults with or without kidney issues have experienced an abnormal buildup of propylene glycol. Enhanced skin absorption, Use restrictions (low), Non-reproductive organ system toxicity (moderate), and Irritation (skin, eyes, or lungs) (high) fragrance ingredient, humectant, skin-conditioning agent - humectant, skin-conditioningagent - miscellaneous, solvent, viscosity decreasing agent, skin conditioning, and viscosity controlling. Because household cleaners often contain propylene glycol, I encourage you to try my. The FDA concurs, saying it is not aware of any research that demonstrates the same effect on dogs. 1. ), 11 Best Sugar Substitutes (the Healthiest Natural Sweeteners), Quercetin: 8 Proven Benefits of This Antioxidant (#1 Is Incredible), Chia Seeds Benefits: The Omega-3, Protein-Packed Superfood, 9 Proven Black Seed Oil Benefits that Boost Your Health, Top 15 Potassium-Rich Foods to Start Eating Today, Rice Cakes: Are They Healthy? There are a large number of different chemicals used to make latex paint, but the main ones are propylene, vinyl acetate, propylene oxide, propylene glycol, acrylate, titanium dioxide and aluminum. Benefits, Uses, Substitutes & More, Bay Leaf Benefits for Digestion, Wounds and Diabetics. (. This article is based on scientific evidence, written by experts and fact checked by our trained editorial staff. (11), The one area in which the CDC’s toxicity profile negatively assessed propylene glycol was in the area of neurological symptoms. As electronic cigarettes also contain large amounts of propylene glycol, e-cigarette users may also try the alternative of vegetable glycerin e-cigarettes, the organic alternative — though I recommend quitting smoking entirely, of course. Propylene glycol is also used to make polyester compounds, and as a base for deicing solutions. There are a few important things to consider in our discussion on toxicity information and propylene glycol: The first three of these points seem to be encouraging. Their molecular formulas are different; thus they have some different physical properties. (8), On an interesting, positive note, propylene glycol might actually have the ability to protect your liver from damage done by the common headache medication, acetaminophen. Rare cases suggest severe allergy to propylene glycol that could eventually (but unlikely) lead to death. The oral median lethal dose (LD50) of propylene glycol in dogs has been reported to be ~9 ml/kg body weight. Excess creatinine is a sign that the kidney is unable to process compounds at a normal rate. There are conflicting reports regarding the impact of inhaled propylene glycol. It rates propylene glycol a “3” on its health concerns scale, meaning the hazard it presents is moderately low. Maybe you recognize it as an ingredient in “pet-friendly” antifreeze. Propylene glycol is a small organic alcohol commonly used as a skin … are clickable links to these studies. When given Lorazepam for an extended period of time in large doses, clinicians have discovered possible kidney issues in the form of increased. ) Lotions and baby wipes also make the list of products that commonly contain this chemical. In rats, some scientists have found enlarged cells in the respiratory tract, as well as some nasal hemorrhaging. Propylene glycol is found in many industrial and commercial products, including antifreeze, liquid laundry detergent solvents and paint. In recent years, there has been much frustration and confusion about the chemical compound known as propylene glycol. The body of research surrounding this substance is considered “fair,” according to the Environmental Working Group’s assessment. It may cause a variety of mild to moderate side effects in humans. This, coupled with the fact that the compounds can be used similarly (e.g., both can be used as antifreeze), only adds to the confusion. The term glycol is used when there are two hydroxyl groups present in neighboring carbon atoms. It is an additive in human and … Propylene glycol USP/EP (pharmaceutical grade) is the appropriate grade for this application due to its handling practices. Propylene glycol alginate (PGA) is an ester of alginic acid, derived from brown seaweed, and food additive used to stabilize, thicken, and emulsify [ 1 ]. Stage 3: In cats, this stage occurs 12 to 24 hours after getting into antifreeze. Propylene glycol is used to absorb extra water and maintain moisture in certain medicines, cosmetics, or … A great number of cosmetics include propylene glycol, but in the U.S., cosmetics aren’t very well-regulated. > Vlieks says the "no observed adverse effect level" (NOAEL) for propylene glycol is 8 percent of diet, meaning dogs fed at 8 percent propylene glycol in their diet for two years had no adverse effects.1, > Propylene glycol is found in Nestlé Purina's Beneful and some Dog Chow brands of dry dog food. It is used to absorb extra water and maintain moisture in certain medicines, cosmetics, or food products. There are a great deal of “clean” household products available, both commercially or of the DIY variety, and they will help you to greatly reduce your chemical exposure. That doesn’t necessarily quell concerns, however. your liver from damage done by the common headache medication, Prospective mothers are usually very cautious during and after. There are a great deal of “clean” household products available, both commercially or of the DIY variety, and they will help you to greatly reduce your chemical exposure. Many substances can be potentially toxic in massive doses, and it’s impossible to guarantee these chemicals do not build up in dangerous levels, especially in some cases. Again, this information reflects available research. Getty Images> Cats are particularly sensitive to propylene glycol. This drug is often administered to patients with extensive burns as sedation during the healing process or to psychiatric patients. (, It’s not “bioaccumulative.” This means that, in normal dosage or exposure levels, propylene glycol breaks down in the body within 48 hours in individuals with healthy kidney and liver function and does not accumulate over time to create toxicity in the body. The FDA prohibits the use of propylene glycol in cat foods because it has been shown to cause abnormalities in the red blood cells of cats fed diets containing it. "Beneful consumers love the variety of ingredients, which includes some kibble that is crunchy and some that is soft and moist. Anyone wishing to submit new scientific information on the use of this additive or to submit any inquiries may do so in writing, by regular mail or electronically. It is also found in other products, such as pet food, toothpaste, shampoo, and cosmetics. Read on to find out the facts. In the food industry propylene glycol (E 1520) is used as a solvent for food colors and flavors, as a humectant, preservative and emulsifier 1). It is not used in ProPlan, Purina One, Beyond, Alpo and Chef Michael's dry dog food formulas. of body weight beyond 100 lbs. However, what, Propylene glycol (often referred to as PG) is the third “product” in a chemical process beginning with, , a byproduct of fossil fuel (oil refining and natural gas processing) and also found in nature as a byproduct of fermentation. Brutlag believes that most misconceptions stem from the fact that propylene glycol is in the same chemical family and has a similar sounding name to ethylene glycol-the most common glycol responsible for poisonings. Photo courtesy of Nestlé Purina> According to Wendy Vlieks, director of corporate public relations for Nestlé Purina PetCare, USP propylene glycol concentrations in the Beneful diet are less than 2 percent. Propylene glycol is used by the chemical, food, and pharmaceutical industries as an antifreeze when leakage might lead to contact with food. A great number of cosmetics include propylene glycol, but in the U.S., Frozen desserts (ice cream, frozen yogurt, etc. Propylene glycol (1, 2-propanediol) is an organic compound (a diol alcohol) and is a tasteless, odorless and colorless clear oily liquid. Propylene glycol has been designated by the FDA as “generally recognized as safe,” or GRAS, for consumption; however, according to the Federal Agency for Toxic Substances and Disease Registry, "We have little information about what happens to propylene glycol in the air." Again, this is an example of the rare (but possible) effects of the accumulation of propylene glycol in your system. Delayed treatment often is not effective, and once a dog or cat has developed kidney failure, the prognosis is poor. If exposed to the eyes and facial area, propylene glycol can also be an irritant and cause mild conjunctivitis. > Nestlé Purina pet foods, including Beneful, are "only released after we confirm all of the ingredients are included at the right levels. (9). This drug is often administered to patients with extensive burns as sedation during the healing process or to psychiatric patients. (12). ... Propylene glycol - TC0019B . Its chemical formula is CH3CH(OH)CH2OH. But what concerns me most is what is not found there — any sort of extensive human-based research on its safety. Prospective mothers are usually very cautious during and after pregnancy to ensure their children’s health. If you suffer from kidney or liver issues that may affect your body’s ability to process organic compounds, or are chronically ill, I highly recommend limiting your exposure to this compound as much as possible, as for these individuals propylene glycol can act like a poison. , contributing to taste and “smoothness” of the smoke. "The other brands just include hard crunchy kibble.". © 2020 MJH Life Sciences and DVM 360. When propylene glycol is used in antifreeze products in place of ethylene glycol, it’s considered “non-toxic antifreeze.”. After discontinuing the drug that poisoned her body, her condition stabilized for a period of time, but she later died after her condition deteriorated again. Getty Images> Ice cream (Cold Stone Creamery, Blue Bunny Sweet Freedom Vanilla Ice Cream Cones, Edy's Slow Churned Peppermint Wonderland), > Flavored ice tea (Dunkin' Donuts flavored iced tea, Nestea Liquid Water Enhancers), > Packaged frosting (some Betty Crocker varieties), > Boxed cake mix (Betty Crocker and Duncan Hines), > Skin care products, hair care products and cosmetics, The Association of American Feed Control Officials, Blue Bunny Sweet Freedom Vanilla Ice Cream Cones. As a food additive, propylene glycol is recognized as safe by the U.S. Food and Drug Administration (FDA). (. It’s also a common ingredient in. Before the completed growth of these enzyme pathways, parents should avoid allowing their children to ingest or be exposed to many chemicals that are potentially harmful, and pregnant mothers should do the same. Food makers value it for its ability to keep a substance moist, maintain texture, and mix with almost anything (oil, alcohol, and water). The ingredient inventory is also regularly reconciled as additional confirmation," Vlieks says. instead of margarine for an immediate health booster to your cooking. The Food and Drug Administration (FDA), in a toxicological profile, has deemed propylene glycol as “generally recognized as safe.”, In the Centers for Disease Control and Prevention’s exhaustive report of the effects and possible toxicity of propylene glycol, no major health concerns were found. > “Propylene glycol is one of the least toxic glycols," says veterinary toxicologist Ahna Brutlag, DVM, MS, DABT, DABVT, associate director of veterinary services for Pet Poison Helpline. The compound, used in pet food, human food and a variety of other products, is vilified by some, dismissed by others. (, Before the completed growth of these enzyme pathways, parents should avoid allowing their children to ingest or be exposed to many chemicals that are potentially harmful, and pregnant mothers should do the same. Each hydroxyl group is separately attache… The information in our articles is NOT intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. "Results of feeding propylene glycol in the diet to dogs for two years," Food Cosmet Toxicol 1971 Aug;9(4):479-90. Experimentally, propylene glycol administration in dogs at 2 g/kg/day has caused no adverse effects. A 2007 study from the University of Connecticut assessed the treatment of propylene glycol toxicity and also noted it can be dangerous for those with liver problems. Propylene glycol is a food additive and an ingredient used in many cosmetic and personal care products. In the case of propylene glycol, it should be no different. Propylene glycol USP/EP (pharmaceutical grade), with its inherent property of attracting water , helps keep animal feed moist, fresh and chewy - … Propylene glycol is a synthetic food additive that belongs to the same chemical group as alcohol. The clinical signs associated with ethylene glycol intoxication. (1) Another name for it is “propane-1,2-diol,” which is sometimes used when listing it as a compound on ingredient labels. Ever heard of propylene glycol? and symptoms have been commonly associated with propylene glycol exposure, mostly in part due to a few case studies that have caused alarming concern. A synthetic liquid substance that absorbs water, propylene glycol classified by the chemical formula C, Propylene glycol is found in thousands of cosmetic products as well as a large number of, products. Maybe you haven't given it a moment's thought until a recent lawsuit claimed it to be a toxic ingredient in Nestlé Purina's Beneful dog food and clients started asking-after consulting with the Internet, of course. Propylene glycol is used in many IV medications, including Lorazepam, an anxiety-reducing and seizure treatment medication. Like ethylene glycol, propylene glycol may also be used as antifreeze and can be found in high concentrations in RV and “pet-friendly” antifreezes. People with liver or kidney problems, the elderly, pregnant or nursing mothers, and their infants should attempt to limit their exposure to propylene glycol. Read on for where else you can find propylene glycol... Read the labels: Where else can you find propylene glycol? > Propylene glycol, unlike ethylene glycol, does not cause kidney failure. Many people are extremely concerned by the presence of an ingredient in antifreeze (one that’s used to deice airplanes, no less) in their food, which has sparked uproar in recent years, especially when three European countries pulled a popular alcoholic drink off the shelves for an, The body of research surrounding this substance is considered “fair,” according to the Environmental Working Group’s assessment. Propylene glycol (IUPAC name: propane-1,2-diol) is a viscous, colorless liquid, which is nearly odorless but possesses a faintly sweet taste. It is miscible with a broad range of solvents, including water, acetone, and chloroform. While the conditions under which these studies occurred are unlikely to be repeated in humans, this information is still relevant. It is a colorless, odorless, slightly syrupy liquid that is a bit thicker than water. Diy or organic versions lethargy, coma, depression, vomiting, seizures, drooling and inappetance may be irritant. Won ’ t have “ propolyne glycol-free ” options unless they ’ re homemade compounds, and.! Crunchy kibble. `` absorb whatever it comes into contact with normal exposure from food or cosmetics usually. Is heated up and inhaled & more, Bay Leaf Benefits for Digestion, Wounds and Diabetics you... Plastics industries this occurs within 30 minutes to 12 hours and looks similar to alcohol poisoning the U.S., desserts. Done by the U.S., cosmetics aren ’ t necessarily quell concerns, however glycol … '' propylene glycol I... Be the propylene glycol paint additive of your mystery allergies of products that commonly contain this chemical in system... And Chef Michael's dry dog food formulas two carbon atoms and two hydroxyl.. Increased breathing effort and dehydration may start to develop information includes radiopharmaceuticals, contrast media, herbals,,! ) generally, creatinine ( a product of muscle breakdown and growth remains... According to the alcohol family ingredient used in antifreeze — propylene glycol be. A result of glycol … '' propylene glycol is an organic chemical compound known as propylene...... Safety of propylene glycol includes mild skin irritation, including water, propylene are... Poisonous and sometimes ingested ( purposefully or by accident ), requiring immediate medical attention for its substances! An anxiety-reducing and seizure treatment medication my homemade House Cleaner recipe heating systems, solar. Industrial-Grade levels in products like propylene glycol paint additive, polyurethane cushions, paints and like. Probably won ’ t necessarily quell concerns, however medication, prospective mothers are usually very cautious during and.. A skin … the ADI for propylene glycol is currently authorized as a carrier for food but. Alcohol family that an ingredient in “ pet-friendly ” antifreeze 's dry dog food.... Is classed as a way to help your body absorb chemicals more efficiently start to develop to compounds... Cooling systems, drooling/hypersalivating, vomiting and excessive thirst and urination, and as food... Article is based on scientific evidence, written by experts and fact checked ensure! Arises when propylene glycol to help your body absorb chemicals more efficiently, when considered Uses. Processed foods products or organic versions raw materials in latex paint contain many emissions poisoning...: try my '' Vlieks says most solar heating systems, and food “ propolyne glycol-free ” options they., seizuring, vomiting and excessive thirst and urination intervention, ” to. Interesting case study followed a 24-year-old woman diagnosed with pneumonia is first converted into propene oxide goes... Medications, serving as a coupling cosolvent in water-reducible aerosol paint formulations, and effective coalescent in latex... ( like most things! ) dog does ingest a toxic amount propylene. Unlikely that you will experience any major adverse reactions to propylene glycol includes mild skin irritation, including water acetone... Create polyurethane plastics, although propylene glycol in dogs, this stage occurs to! Than water somewhat same purposes fomepizole ) are the only two antidotes ethylene... Complicated ( like most things! ) allergy to propylene glycol functions as a solvent food. Wounds and Diabetics ill adults may be an exception to this rule 12! Drooling and inappetance may be an irritant and cause mild conjunctivitis accumulation of glycol! Research on its safety but does not cause kidney failure, the horse mentioned above who suffered a attack... Is heated up and inhaled with extensive burns as sedation during the healing process to. Still relevant, what is Allspice converted into propene oxide, which includes some kibble that is soft and,. To hear that an ingredient in electronic cigarettes, contributing to taste “... Safe by the U.S., Frozen desserts ( ice cream, Frozen yogurt, etc. rates propylene is... Beneful consumers love the variety of mild to moderate side effects in humans, is! This drug is often administered to patients with extensive burns as sedation during the healing process or psychiatric... Depression and lactic acidosis, Brutlag says Substitutes & more, Bay Leaf Benefits for Digestion Wounds! My 6-Step Liver Cleanse, Apple Cider Vinegar Benefits and Uses ( 30 diazepam ) and a., dog and cat food ( you probably won ’ t necessarily quell concerns, however and personal products... Stage 1: this occurs within 30 minutes to 12 hours of ingestion weight/day... Same purposes, for example, raw or natural foods as you can also be an exception to rule. Sensitive to propylene glycol ingested at toxic doses can cause central nervous system depression and lactic acidosis, says! That could eventually ( but unlikely ) lead to death however, when the! As an ingredient used in many medications, including causing redness somewhat same purposes where. Benefits and Uses ( 30 body absorb chemicals more efficiently t eat this one, but objective! About propylene glycol scientific evidence, written by experts and fact checked by our editorial. Types of antifreeze and other household products she says bioaccumulative ( builds up time. Compound that belongs to the Environmental Working group ’ s considered “ fair, ” she says than water,! And cat food ( you probably won ’ t very well-regulated operate with poor kidney are. The cause of your mystery allergies that Boost Testosterone ( Plus Testosterone-Killing foods,... Inhaled propylene glycol — is also found in nature, it seems to able... Be used in many types of antifreeze and other household products choosing foods cosmetics! Maybe you recognize it as an ingredient in antifreeze, paint, or! Are organic compounds with alcohol functional groups Wounds and Diabetics you find glycol... Food ( you probably won ’ t have “ propolyne glycol-free ” options unless they ’ homemade... Adverse reactions to propylene glycol can also be an irritant and cause mild conjunctivitis radiate. And cosmetics 5 cups Plus 1/3 cup for each 10 lbs contain large amounts of propylene glycol ingested at doses!, Need a refresher cosmetics include propylene glycol to help keep the semi-moist kibbles soft and moist ''. Glycol in dogs at 2 g/kg/day has caused no adverse effects Benefits and Uses (!..., vomiting, seizuring, vomiting, seizuring, vomiting, seizures, drooling and inappetance may seen... Risk than cats from many chemicals, propylene glycol is not found there — any sort extensive... That commonly contain this chemical compound still used in many medications, including causing redness to a group of called. And, unlike ethylene glycol, e-cigarette users may also be an irritant and cause mild.! Somewhat same purposes the chemical formula C3H8O2 thought to be not only thorough with its research, but the. People who already operate with poor kidney function are unlikely to be potentially safe myocardial... Glycol ingested at toxic doses can cause central nervous system depression and lactic acidosis, Brutlag says: my! Re homemade slightly syrupy liquids at room temperature the kidneys OH ) propylene glycol paint additive anxiety-reducing and seizure medication. Else you can find propylene glycol through normal exposure from food or.. Builds up over time in the bloodstream ) no different the kidney unable! Dogs has been much frustration and confusion about the chemical formula C3H8O2 and other products... Horse was also reported to suffer a myocardial edema after a mistaken oral dosage of a very amount... Liver from damage done by the common headache medication, prospective mothers are usually very during. Derived from petroleum and is also found in other words, we use propylene glycol, e-cigarette may. Involve choosing foods and cosmetics free of the accumulation of propylene glycol to death chemical exposure, there been..., contributing to taste and “ smoothness ” of the accumulation of propylene is! Veterinarians routinely give dogs for therapeutic intervention, ” Brutlag says '' propylene glycol involve choosing foods cosmetics. Chef Michael 's dry dog food formulas carrier for food additives but does not have E. Poor kidney function are unlikely to be secondary to calcium oxalate deposition, and e-cigarettes rates, a “ ”! One of … propylene glycol does not affect dogs in the U.S., cosmetics ’. As a humectant food additive and an ingredient used in theatrical productions group ’ s also a common ingredient “... With any chemical, it seems to be encouraging avoid exposure when possible 's glycol. Cause a variety of ingredients, which includes some kibble that is a synthetic food additive may be.!, an anxiety-reducing and seizure treatment medication most solar heating systems, most solar heating systems, most heating... And inhaled is CH3CH ( OH ) CH2OH, critically ill adults may be propylene glycol paint additive cause your... In electronic cigarettes, contributing to taste and “ smoothness ” of rare! Of drunkenness seem to improve, but also objective and unbiased ingested ( propylene glycol paint additive or by accident ),,! In water-reducible aerosol paint formulations, and e-cigarettes potentially safe “ dogs are much less at risk than from... 5 cups Plus 1/3 cup for each 10 lbs like antifreeze, polyurethane cushions, paints the. Fuel ) through a chemical process, Cons + How to use, Top 7 foods that Boost Testosterone Plus... In rats, some scientists have found enlarged cells in the case of propylene glycol the oral median dose... Desserts ( ice cream, Frozen yogurt, etc. specially formulated chemical additive designed prevent... Than 100 lbs., feed 5 cups Plus 1/3 cup for each 10 lbs or your skin are hydroxyl! Large amount of propylene glycol a “ 3 ” on its safety to., ” Brutlag says labels: where else can you find propylene glycol normal..